D3-βArr是一种促甲状腺激素受体正变构调节剂，通过促甲状腺激素受体直接激活启动β-Arr1的易位，并增强促甲状腺激素介导的体外成骨细胞分化。
| Cas No. | 662164-09-2 |
| 别名 | 2-甲氧基-4-(4-甲基哌嗪-1-基)苯胺 |
| Canonical SMILES | CC(NC1=C2C=CC=CC2=NC(N3CCNCC3)=N1)C4=CC=CC=C4 |
| 分子式 | C20H23N5 |
| 分子量 | 333.43 |
| 溶解度 | DMSO: ≥ 125 mg/mL (374.89 mM) |
| 储存条件 | 4℃, away from moisture |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | D3-βArr is a positive allosteric modulator for thyrotropin receptor (TSHR), which initiates translocation of β-Arr 1 by direct TSHR activation and potentiates TSH-mediated preosteoblast differentiation in vitro[1]. [1]. Neumann S, et al. Discovery of a Positive Allosteric Modulator of the Thyrotropin Receptor: Potentiation of Thyrotropin-Mediated Preosteoblast Differentiation In Vitro. J Pharmacol Exp Ther. 2018 Jan;364(1):38-45. |
