21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

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CAS NO:

37413-91-5

包装与价格：

包装	价格(元)
10mM (in 1mL DMSO)	询价
10mg	询价
25mg	询价

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione是delta9,11类固醇类合成的中间体(intermediate)，如Vamorolone 。delta9,11steroids是糖皮质激素的修饰后的产物，具有抗炎(anti-inflammatory)特性。delta9,11类固醇类可以用作保护细胞损伤(脂质过氧化)和抑制新生血管的试剂。

Cas No.	37413-91-5
别名	21-羟基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯
Canonical SMILES	C[C@@]12[C@](CC=C2C(COC(C)=O)=O)([H])[C@@]3([H])C([C@@]4(C(CC3)=CC(C=C4)=O)C)=CC1
分子式	C₂₃H₂₆O₄
分子量	366.45
溶解度	DMSO: 100 mg/mL (272.89 mM)
储存条件	Store at -20℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone . The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1]. δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids[1].VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability[1]. [1]. Erica K M Reeves, et al. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem