(S)-Verapamil D7 hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装:	1mg
市场价:	2070元

(S)-VerapamilD7hydrochloride((S)-(-)-VerapamilD7hydrochloride)是(S)-Verapamilhydrochloride的一种氘代化合物。(S)-Verapamilhydrochloride(S(-)-Verapamilhydrochloride)通过MRP1抑制白三烯C4(LTC4)和钙黄绿素的转运。(S)-Verapamilhydrochloride导致潜在耐药性肿瘤细胞死亡。

别名	(S)-(-)-Verapamil D7 hydrochloride
Canonical SMILES	Cl[H].COC1=C(OC)C=CC(CCN(C)CCC[C@@](C#N)(C2=CC(OC)=C(OC)C=C2)C(C([2H])([2H])[2H])([2H])C([2H])([2H])[2H])=C1
分子式	C₂₇H₃₂D₇ClN₂O₄
分子量	498.11
储存条件	Store at -20℃
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	(S)-Verapamil D7 hydrochloride ((S)-(-)-Verapamil D7 hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells[1][2]. [1]. Perrotton T, et al. (R)- and (S)-verapamil differentially modulate the multidrug-resistant protein MRP1. J Biol Chem. 2007 Oct 26;282(43):31542-8. Epub 2007 Jul 22. [2]. Tannergren C, et al. St John's wort decreases the bioavailability of R- and S-verapamil through induction of the first-pass metabolism. Clin Pharmacol Ther. 2004 Apr;75(4):298-309.