2-Methylthioadenosine diphosphate trisodium

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CAS NO:	475193-31-8
包装:	5mg
市场价:	4680元

2-Methylthioadenosinediphosphatetrisodium(2-Methylthio-ADPtrisodium)是一种有效的嘌呤能P2Y受体激动剂，对人P2Y13、小鼠P2Y13和人P2Y12的EC50分别为19、6.2和5nM。2-Methylthioadenosinediphosphatetrisodium对人P2Y1和大鼠P2Y6的pEC50分别为8.29和5.75。2-Methylthioadenosinediphosphatetrisodium诱导血小板聚集和形态改变，并抑制前列腺素E1作用下血小板内环腺苷酸的积累。

Cas No.	475193-31-8
别名	2-甲基硫代二磷酸腺苷,2-Methylthio-ADP trisodium
Canonical SMILES	O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](O[Na])(O[Na])=O)(O[Na])=O)([H])N2C3=NC(SC)=NC(N)=C3N=C2
分子式	C₁₁H₁₄N₅Na₃O₁₀P₂S
分子量	539.24
溶解度	PBS (pH 7.2): 10 mg/mL,Water: soluble
储存条件	Store at -20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	2-Methylthioadenosine diphosphate trisodium is a potent purinergic P2Y receptors agonist, with EC50s of 19, 6.2, and 5 nM for human P2Y13, mouse P2Y13 and human P2Y12, respectively. 2-Methylthioadenosine diphosphate trisodium has pEC50s of 8.29 and 5.75 for human P2Y1 and rat P2Y6, respectively. 2-Methylthioadenosine diphosphate trisodium induces platelet aggregation and shape change, and inhibits cyclic AMP accumulation in platelets exposed to prostaglandin E1[1][2][3]. 2-Methylthioadenosine diphosphate trisodium (2-Methylthio-ADP trisodium) is a powerful aggregating agent for human platelets. 2-Methylthioadenosine diphosphate trisodium is also a powerful inhibitor of the accumulation of cyclic AMP in intact platelets exposed to PGE1 and a phosphodiesterase inhibitor[1]. [1]. Zhang FL, et al. P2Y(13): identification and characterization of a novel Galphai-coupled ADP receptor from human and mouse. J Pharmacol Exp Ther. 2002;301(2):705-713. [2]. Sak K, et al. A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch Biochem Biophys. 2002;397(1):131-136. [3]. Macfarlane DE, et al. 2-Methylthioadenosine[beta-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J Clin Invest. 1983;71(3):420-428.