Tetramethylglycerol (Tetramethylglycoluril) 是一种作用于 GABA 受体的小分子，具有抗焦虑活性。
| Cas No. | 10095-06-4 |
| 别名 | 2,4,6,8-四氮杂双环[3.3.0]辛烷-3,7-二酮,2,4,6,8-四甲基-,Tetramethylglycoluril; Mebicar |
| Canonical SMILES | O=C1N(C2N(C)C(N(C2N1C)C)=O)C |
| 分子式 | C8H14N4O2 |
| 分子量 | 198.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Mebicar is an anxiolytic with antiepileptic activity.1,2In vivo, mebicar (10 mg/kg) reduces anxiety-like behavior and decreases stress-induced increases in serum corticosterone and pro-inflammatory cytokine levels in a mouse model of intermittent unpredictable stress.1It inhibits epileptic activity in a rat model of penicillin-induced focal epilepsy.2 1.Kim, C.Y., Kim, Y.G., Sin, S.J., et al.Preventive effect of mebicar and ginsenoside Rg1 on neurobehavioral and immunological disruptions caused by intermittent unpredictable stress in miceNeuroImmunoModulation25(1)49-58(2018)
2.Rekhtman, M.B., Torshin, V.I., and Darinski?, N.V.Effect of mebikar on focal epileptic activityBiull. Eksp. Biol. Med.91(2)178-181(1981) |
