Quassin is a quassinoid that has been found inQ. amaraand has diverse biological activities.^1,2,3It is active against chloroquine-sensitive and -resistant strains ofP. falciparum(IC₅₀= 0.15 µM for both).¹Quassin has antifeedant and insecticidal activity against the diamondback moth (P. xylostella) when applied to dietary cabbage leaf discs at 16, 31.9, or 63.7 µg/cm².²It increases viability of SH-SY5Y cells in a model of hydrogen peroxide-induced neuronal injury when used at concentrations of 25, 50, or 100 µM.³

1.Mishra, K., Chakraborty, D., Pal, A., et al.Plasmodium falciparum: in vitro interaction of quassin and neo-quassin with artesunate, a hemisuccinate derivative of artemisininExp. Parasitol.124(4)421-427(2010) 2.Daido, M., Fukamiya, N., Okano, M., et al.Antifeedant and insecticidal activity of quassinoids against diamondback moth (Plutella xylostella)Biosci. Biotechnol. Biochem.57(2)2440246(1993) 3.He, C., Wang, Y., Yang, T., et al.Quassinoids with insecticidal activity against Diaphorina citri Kuwayama and neuroprotective activities from Picrasma quassioidesJ. Agric. Food. Chem.68(1)117-127(2020)