Galanin(2-11)amide(human,mouse,rat,porcine,bovine,ovine)(trifluoroacetate salt)

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
500 µg	询价
1mg	询价
5mg	询价
10mg	询价

A synthetic peptide fragment of galanin and an agonist of the GAL₂receptor

Canonical SMILES	N[C@H](C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CO)C(N[C@@H](C)C(NCC(N[C@H](C(N[C@@H](CC(C)C)C(N[C@H](C(N)=O)CC(C)C)=O)=O)CC(C=C1)=CC=C1O)=O)=O)=O)=O)=O)=O)=O)CC2=CNC3=CC=CC=C23.OC(C(F)(F)F)=O
分子式	C₅₄H₈₁N₁₃O₁₄·XCF₃COOH
分子量	1136.3
溶解度	DMF: 5 mg/ml,DMSO: 5 mg/ml
储存条件	-20°C
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Galanin (2-11) amide is a synthetic peptide fragment of the neuropeptide galanin and an agonist of the galanin-2 (GAL₂) receptor (EC₅₀= 9.32 nM in a fluorescence imaging plate reader assay).¹It selectively binds to the GAL₂receptor (IC₅₀= 1.76 nM for the rat receptor) over the GAL₁receptor (IC₅₀= 879 nM for the human receptor) but does also bind to the GAL₃receptor (K_i= 271 nM for the rat receptor).^1,2Intracerebroventricular administration of galanin (2-11) amide (1 nmol/animal) decreases immobility in the forced swim test in rats.³It also reduces the hind paw mechanical pain threshold and increases the hind paw cold sensitivity threshold in rats.¹ 1.Liu, H.-X., Brumovsky, P., Schmidt, R., et al.Receptor subtype-specific pronociceptive and analgesic actions of galanin in the spinal cord: Selective actions via GalR1 and GalR2 receptorsProc. Natl. Acad. Sci. USA98(17)9960-9964(2001) 2.Lu, X., LundstrÖm, L., and Bartfai, T.Galanin (2-11) binds to GalR3 in transfected cell lines: Limitations for pharmacological definition of receptor subtypesNeuropeptides39(3)165-167(2005) 3.Kuteeva, E., Wardi, T., LundstrÖm, L., et al.Differential role of galanin receptors in the regulation of depression-like behavior and monoamine/stress-related genes at the cell body levelNeuropsychopharmacology33(11)2573-2585(2008)