Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) 是非选择性的，长效的钙离子通道 (Ca+ channel) 拮抗剂，钠离子、钾离子通道 (Na+, K+ channel) 抑制剂，具有抗心绞痛和抗 I 型心律失常作用。Bepridil hydrochloride hydrate 也是心脏 Na+/Ca2+ 交换 (NCX1) 抑制剂。Bepridil hydrochloride hydrate 可用于心血管疾病的研究。
| Cas No. | 74764-40-2 |
| 别名 | 盐酸苄普地尔,(±)-Bepridil hydrochloride hydrate; Org 5730 hydrochloride hydrate |
| Canonical SMILES | CC(C)COCC(N1CCCC1)CN(C2=CC=CC=C2)CC3=CC=CC=C3.[H]Cl.[H]O[H] |
| 分子式 | C24H37ClN2O2 |
| 分子量 | 421.02 |
| 溶解度 | DMSO: ≥ 250 mg/mL (593.80 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Bepridil hydrochloride hydrate ((±)-Bepridil hydrochloride hydrate) is a non-selective, long-acting Ca+ channel antagonist and Na+, K+ channel inhibitor, with antianginal and type I antiarrhythmic effects. Bepridil hydrochloride hydrate also acts as a cardiac Na+/Ca2+ exchange (NCX1) inhibitor. Bepridil hydrochloride hydrate can be used for the research of cardiovascular disorders[1][2][3][4][5]. [1]. A Gill, et al. Pharmacology of Bepridil. Am J Cardiol. 1992 Apr 9;69(11):11D-16D.
[2]. D R Harder, et al. Bepridil Blockade of Ca2+-dependent Action Potentials in Vascular Smooth Muscle of Dog Coronary Artery. J Cardiovasc Pharmacol. Jul-Aug 1981;3(4):906-14.
[3]. Yasuhide Watanabe. Cardiac Na +/Ca 2+ Exchange Stimulators Among Cardioprotective Drugs. J Physiol Sci. 2019 Nov;69(6):837-849.
[4]. A Yatani, et al. Bepridil Block of Cardiac Calcium and Sodium Channels. J Pharmacol Exp Ther. 1986 Apr;237(1):9-17.
[5]. J C Wang, et al. Bepridil Differentially Inhibits Two Delayed Rectifier K(+) Currents, I(Kr) and I(Ks), in Guinea-Pig Ventricular Myocytes. Br J Pharmacol. 1999 Dec;128(8):1733-8.
[6]. L Z Benet, et al. Pharmacokinetics and Metabolism of Bepridil. Am J Cardiol. 1985 Mar 15;55(7):8C-13C. |
