CBA (CBA) 是阳离子通道 TRPM4 的有效选择性抑制剂，IC50 为 1.5 μM.
| Cas No. | 351424-20-9 |
| 别名 | CBA |
| Canonical SMILES | OC(C1=C(C=C(C=C1)Cl)NC(COC2=C(C=CC=C2)Cl)=O)=O |
| 分子式 | C15H11Cl2NO4 |
| 分子量 | 340.16 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Selective TRPM4 blocker (IC50 = 1.5 μM). Exhibits no significant activity against TRPM5, TRPM7, TRPM8, TRPV1, TRPV3, TRPV6 and a range of other ion channels and receptors. Displays neuroprotective effects against glutamate-induced neurodegeneration in vitro. Bianchi et al (2018) The ion channel TRPM4 in murine experimental autoimmune encephalomyelitis and in a model of glutamate-induced neuronal degeneration. Mol.Brain. 11 41 PMID:29996905 |Ozhathil et al (2018) Identification of potent and selective small molecule inhibitors of the cation channel TRPM4. Br.J.Pharmacol. 175 2504 PMID:29579323 |
