PSEM 89S 是产生离子通道的选择性和脑渗透激动剂。
| Cas No. | 1336913-03-1 |
| Canonical SMILES | OC(C(F)(F)F)=O.O=C(N[C@@H]1CN2CCC1CC2)C(C=C3OC)=C(C=C3)OC |
| 分子式 | C16H22N2O3.CF3CO2H |
| 分子量 | 404.38 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist (EC50 values are 3.4 and 2.2 μM, respectively). Activates cortical neurons expressing PSAML141F,Y115F-5-HT3 chimeric ion channels and inhibits activity of neurons expressing PSAML141F-GlyR in vitro. Silences hypothalamic AGRP neurons transfected with PSAML141F-GlyR chimeric ion channels in mice in vivo, leading to suppression of feeding. Brain penetrant. Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene. Magnus et al (2011) Chemical and genetic engineering of selective ion channel-ligand interactions. Science 333 1292 PMID:21885782 |Cerritelli et al (2016) Activation of brainstem pro-opiomelanocortin neurons produces opioidergic analgesia, bradycardia and bradypnoea. PLoS One 11 e0153187 PMID:27077912 |
