Z 944 是一种口服活性 T 型钙通道拮抗剂，可挽救交叉模式和视觉识别记忆的损伤。
| Cas No. | 1199236-64-0 |
| 别名 | N-((1-(2-(叔丁基氨基)-2-氧代乙基)哌啶-4-基)甲基)-3-氯-5-氟苯甲酰胺,Z944 |
| Canonical SMILES | CC(C)(NC(CN1CCC(CC1)CNC(C2=CC(Cl)=CC(F)=C2)=O)=O)C |
| 分子式 | C19H27ClFN3O2 |
| 分子量 | 383.89 |
| 溶解度 | Chloroform: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Selective T-type Ca2+ channel blocker (IC50 values are 50 to 160 nM for hCav3.1, hCav3.2 and hCav3.3). Exhibits 50 to 600 fold selectivity for Cav3.x channels over related ion channels (Cav1.2, hERG and Nav1.5). Has no effect on action potential properties in isolated heart Purkinje fibers and no adverse effects on ECG parameters in vivo. Exhibits anti-seizure effects in animal models. Tringham et al (2012) T-type calcium channel blockers that attenuate thalamic burst firing and suppress absence seizures. Sci.Transl.Med. 4 121 PMID:22344687 |Casillas-Espinosa et al (2015) Z944, a novel selective T-type calcium channel antagonist delays the progression of seizures in the amygdala kindling model. PLoS One. 10 e0130012 PMID:26274319 |
