ASP 7663 是一种具有口服活性和选择性的 TRPA1 激动剂。
| Cas No. | 1190217-35-6 |
| Canonical SMILES | O=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O |
| 分子式 | C14H14FNO3 |
| 分子量 | 263.26 |
| 溶解度 | DMSO: 25 mg/ml,Ethanol: 25 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Selective TRPA1 activator (EC50 values are ~0.5 μM in human, mouse and rat). Displays little or no affinity at more than 60 other related receptors, channels and enzymes. Stimulates 5-HT release from QGP-1 cells. Exhibits an abdominal analgesic effect in vivo. Orally bioavailable. Kojima et al (2014) Effects of novel TRPA1 receptor agonist ASP7663 in models of drug-induced constipation and visceral pain. Eur.J.Pharmacol. 723 288 PMID:24291101 |
