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FSG67
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
FSG67图片
CAS NO:1158383-34-6
包装与价格:
包装价格(元)
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FSG67 是一种甘油 3-磷酸酰基转移酶 (GPAT) 抑制剂,IC50 为 24 μM。
Cas No.1158383-34-6
分子式C16H25NO4S
分子量327.44
溶解度DMSO : 100 mg/mL (305.40 mM; Need ultrasonic)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

FSG67 is a glycerol 3-phosphate acyltransferase (GPAT) inhibitor with an IC50 of 24 μM[1].

FSG67 reduces GSK3β phosphorylation and signaling after acetaminophen overdose[1].FSG67 results in a dose-dependent increase in oxidative metabolism in mature adipocytes with an IC50 of 27.7 ± 4.4 μM[2].

[1]. Clemens MM, et al. The inhibitor of glycerol 3-phosphate acyltransferase FSG67 blunts liver regeneration after acetaminophen overdose by altering GSK3β and Wnt/β-catenin signaling. Food Chem Toxicol. 2019 Mar;125:279-288. [2]. Reilly SM, et al. Catecholamines suppress fatty acid re-esterification and increase oxidation in white adipocytes via STAT3. Nat Metab. 2020 Jul;2(7):620-634.

 
 
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