Isoflupredone acetate 是一种具有抗炎活性的皮质类固醇。Isoflupredone acetate 可用于研究牛、马、猪等动物的酮症、肌肉骨骼疾病、过敏、感染、炎症等疾病。
| Cas No. | 338-98-7 |
| 别名 | 醋酸异氟泼尼松 |
| 分子式 | C23H29FO6 |
| 分子量 | 420.47 |
| 溶解度 | DMSO : 125 mg/mL (297.29 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Isoflupredone acetate is a corticosteroids with anti-inflammatory activity. Isoflupredone acetate can be used for research ketosis, musculoskeletal disorders, hypersensitivity, infections, inflammatory diseases in cows, horse, pigs, et al.[1][2]. Isoflupredone acetate (10-4, 10-7, or 10-10M; 48 or 96 h)mitigates the inflammatory and catabolic effects of IL-1β in synovial and osteochondral explants (from equine cadavers) to a greater extent in low concentrations (10-7M and 10-10M) than the high concentration (10-4M)[1]. Isoflupredone acetate (0.05 mg/kg; i.m.; on days 2 and 4 after the challenge) prevents dry-matter intake and average daily gain reductions, and leads to fasterMannheimia haemolytica-infected clinical improvement when co-treated withOxytetracycline[2]. | Animal Model: | 96 weanling heifers (Bronchopneumonia was induced by intrabronchial infusion ofMannheimia haemolytica)[2] | | Dosage: | 0.05 mg/kg | | Administration: | i.m.; on days 2 and 4 after the challenge | | Result: | Infection caused a reduction in dry-matter intake and average daily gain (ADG) in heifers.Prevented these reductions and resulted in faster clinical improvement when co-treated withOxytetracycline. |
|
