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C16 Ceramide-d7(d18:1-d7/16:0)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C16 Ceramide-d7(d18:1-d7/16:0)图片
CAS NO:1840942-13-3
包装与价格：
包装价格(元)
500 μg询价
1mg询价

An internal standard for the quantification of C-16 ceramide
Cas No.1840942-13-3
别名Palmitoyl Ceramide-d7
化学名N-[2R-hydroxy-1S-(hydroxymethyl)-3E-heptadecen-1-yl-d7]-hexadecanamide
Canonical SMILESOC[C@H](NC(CCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCC([2H])([2H])C([2H])([2H])C([2H])([2H])[2H]
分子式C34H60D7NO3
分子量545
溶解度DMF: 0.15 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
文献引用
产品描述

C16 Ceramide-d7 is intended for use as an internal standard for the quantification of C16 ceramide by GC- or LC-MS. C16 Ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling.[1] Accumulation of C16 ceramide through PPMP (30 μM) or MAPP (50 μM) treatment or from addition of 100 μM synthetic C16 ceramide induces apoptosis in neutrophil cultures via caspase-3 activation.[2]

Reference:
[1].White-Gilbertson, S., Mullen, T., Senkal, C., et al.Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cellsOncogene28(8)1132-1141(2009)
[2].Seumois, G., Fillet, M., Gillet, L., et al.De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosisJ. Leukoc. Biol.81(6)1477-1486(2007)

 
 
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