Ponicidin(RubescensineB)是源于冬凌草的二萜，具有免疫调节、抗炎、抗病毒和抗癌作用。Ponicidin(RubescensineB)可诱导胃癌细胞凋亡(apoptosis)，降低JAK2和STAT3的磷酸化水平，单对其蛋白水平无作用。
| Cas No. | 52617-37-5 |
| 别名 | 冬凌草乙素,Rubescensine B |
| Canonical SMILES | O[C@]12[C@]3(C4=O)[C@]5([H])C6([C@](O[C@@]3([H])[C@](CC5)([H])C4=C)([H])O2)[C@](C(C)(CC[C@@H]6O)C)([H])[C@@H]1O |
| 分子式 | C20H26O6 |
| 分子量 | 362.42 |
| 溶解度 | DMSO: 250 mg/mL (689.81 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Ponicidin (Rubescensine B) is a diterpenoid derived from Rabdosia rubescens, and exhibits immunoregulatory, anti-inflammatory, anti-viral and anti-cancer activity. Ponicidin (Rubescensine B) induces apoptosis of gastric carcinoma cell, decreases the phosphorylation of JAK2 and STAT3, and shows no effect on protein levels of JAK2 and STAT3[1]. [1]. Liu YF, et al. Ponicidin induces apoptosis via JAK2 and STAT3 signaling pathways in gastric carcinoma. Int J Mol Sci. 2015 Jan 12;16(1):1576-89. |
