MS-1020 是一种有效的 ATP 竞争性 JAK3 抑制剂。 MS-1020 抑制 JAK3/STAT 信号传导并诱导细胞凋亡。 MS-1020 促进细胞死亡。 MS-1020 降低酪氨酸磷酸化 STAT3 水平的表达。 MS-1020 具有研究携带异常 JAK3 信号的癌症的潜力。
| Cas No. | 1255516-86-9 |
| Canonical SMILES | O=C(C1=CC=C(C=CC=C2)C2=C1O)NCCC3=CNC4=C3C=C(O)C=C4 |
| 分子式 | C21H18N2O3 |
| 分子量 | 346.4 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | MS-1020 is a cell-permeable inhibitor of janus kinase 3 (JAK3), strongly inhibiting constitutive autophosphorylation of JAK3 in L540 cells when used at 30-50 μM. It is without effect on other JAK isoforms and several other kinases, including Src, Lyn, Akt, EGFR, and ERK1/2. Through its effects on JAK3, MS-1020 blocks phosphorylation of downstream signal transduction and activators of transcription isoforms, reducing the expression of anti-apoptotic genes, leading to cell death. |
