SGC-iMLLT是一种有效、选择性的MLLT1/3-histone相互作用抑制剂，与MLLT1YD上的Kac/Kcr结合位点结合，对MLLT1YD(ENL/YEATS1)(IC50,0.26 μM;Kd,0.129 μM)和MLLT3YD(AF9/YEATS3)(Kd,0.077 μM)具有很高的亲和性。
| Cas No. | 2255338-25-9 |
| Canonical SMILES | CN1N=CC2=CC(C(NC3=CC=C(NC(CN4[C@@H](C)CCC4)=N5)C5=C3)=O)=CC=C21 |
| 分子式 | C22H24N6O |
| 分子量 | 388.47 |
| 溶解度 | DMSO : 83.33 mg/mL (214.51 mM);Water :< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interactions, occupies the Kac/Kcr binding site of MLLT1 YD (ENL/YEATS1), with high binding activity at MLLT1 YD (IC50, 0.26 μM; Kd, 0.129 μM) and MLLT3 YD (AF9/YEATS3) (Kd, 0.077 μM)[1].
IC50: 0.26 μM (MLLT1 YD)[1]Kd: 0.077 μM (MLLT3 YD), 0.129 μM (MLLT1 YD)[1] [1]. Moustakim M, et al. Discovery of an MLLT1/3 YEATS Domain Chemical Probe. Angew Chem Int Ed Engl. 2018 Dec 10;57(50):16302-16307. |
