5,7-Dimethoxyflavone是Kaempferiaparviflora的主要成分之一，具有抗肥胖，抗炎和抗肿瘤作用。5,7-Dimethoxyflavone抑制细胞色素P450(CYP)3As。5,7-Dimethoxyflavone也是有效的抗乳腺癌蛋白(BCRP)抑制剂。
| Cas No. | 21392-57-4 |
| 别名 | 柯因二甲醚 |
| Canonical SMILES | O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=CC(OC)=C13 |
| 分子式 | C17H14O4 |
| 分子量 | 282.29 |
| 溶解度 | DMSO: 100 mg/mL (354.25 mM) |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 5,7-Dimethoxyflavone is one of the major components of Kaempferia parviflora, has anti-obesity, anti-inflammatory, and antineoplastic effects. 5,7-Dimethoxyflavone inhibits cytochrome P450 (CYP) 3As. 5,7-Dimethoxyflavone is also a potent Breast Cancer Resistance Protein (BCRP) inhibitor[1][2]. [1]. Ochiai W, et al. Effect of the active ingredient of Kaempferia parviflora, 5,7-dimethoxyflavone, on the pharmacokinetics of midazolam. J Nat Med. 2018 Jun;72(3):607-614.
[2]. Bae S, et al. Effect of 5,7-dimethoxyflavone on Bcrp1-mediated transport of sorafenib in vitro and in vivo in mice. Eur J Pharm Sci. 2018 May 30;117:27-34. |
