Cobimetinib（消旋体）（GDC-0973 消旋体；XL518 消旋体）是 Cobimetinib 的消旋体。 Cobimetinib 是一种有效的选择性 MEK 抑制剂。
| Cas No. | 934662-91-6 |
| 别名 | 考比替尼 (外消旋体); GDC-0973 racemate; XL518 racemate |
| 化学名 | [3,4-difluoro-2-(2-fluoro-4-iodoanilino)phenyl]-(3-hydroxy-3-piperidin-2-ylazetidin-1-yl)methanone |
| Canonical SMILES | C1CCNC(C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O |
| 分子式 | C21H21F3IN3O2 |
| 分子量 | 531.31 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Cobimetinib racemate (GDC-0973 racemate; XL518 racemate) is the less active racemate of Cobimetinib. Cobimetinib is a potent and selective MEK inhibitor. References:
[1]. Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9. |
