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2-Keto Crizotinib(PF-06260182)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Keto Crizotinib(PF-06260182)图片
CAS NO:1415558-82-5

2-Keto Crizotinib (PF-06260182) (PF-06260182) 是 crizotinib 的活性内酰胺代谢物。
Cas No.1415558-82-5
别名克里唑替尼杂质,PF-06260182
Canonical SMILESO=C1CC(N2N=CC(C3=CC(O[C@H](C)C4=C(Cl)C(F)=CC=C4Cl)=C(N)N=C3)=C2)CCN1
分子式C21H20Cl2FN5O2
分子量464.32
溶解度Soluble in DMSO
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Keto Crizotinib (PF-06260182) is an active lactam metabolite of crizotinib.

2-Keto Crizotinib (PF-06260182) is active and considerably less potent than crizotinib, and it is not thought to contribute significantly to the in vivo activity of crizotinib.

[1]. Balis FM, e al. First-dose and steady-state pharmacokinetics of orally administered crizotinib in children with solid tumors: a report on ADVL0912 from the Children's Oncology Group Phase 1/Pilot Consortium. Cancer Chemother Pharmacol. 2017 Jan;79(1):181-187.

 
 
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