T338CSrc-IN-1是突变型c-SrcT338C高效抑制剂，IC50值111nM。对WTSrc活性弱10倍以上。
| Cas No. | 1351926-90-3 |
| Canonical SMILES | NC1=C2C(N(C(C)C)N=C2CC3=CC(NS(=O)(C=C)=O)=CC=C3)=NC=N1 |
| 分子式 | C17H20N6O2S |
| 分子量 | 372.44 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase). [1]. Garske AL, et al. Chemical genetic strategy for targeting protein kinases based on covalent complementarity. Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15046-52. |
