BRD 6989 是天然产物皮质抑素 A (dCA) 的类似物，可抑制 CDK8 并上调 IL-10。
| Cas No. | 642008-81-9 |
| Canonical SMILES | CC1CCC2=NC(N)=C(C(C3=CN=CC=C3)=C2C1)C#N |
| 分子式 | C16H16N4 |
| 分子量 | 264.33 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Binds and inhibits Cdk8 in complex with cyclin C (IC50 ~ 200 nM). Enhances IL-10 production in activated human and murine macrophages and dendritic cells (EC50 is approximately 1 μM for IL-10 production in bone marrow-derived dendritic cells). Also inhibits CDK19 in complex with cyclin C. Johannessen et al (2017) Small-molecule studies identify CDK8 as a regulator of IL-10 in myeloid cells. Nat.Chem.Biol. 13 1102 PMID:28805801 |
