| CAS NO: | 2250019-92-0 |
| 包装: | 5mg |
| 市场价: | 3822元 |
| Cas No. | 2250019-92-0 |
| 别名 | AMG-18 Hydrochloride |
| Canonical SMILES | CC1=C(C2=C(C(NS(=O)(C3=C(C=CC=C3)Cl)=O)=CC=C2)C=C1)OC4=C(C5=NC(N[C@H]6CCCNC6)=NC=C5)C=CC=N4.Cl |
| 分子式 | C31H29ClN6O3S.HCl |
| 分子量 | 637.58 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Potent and selective IRE1α inhibitor (IC50 values are 13 and 99 nM for recombinant and cellular IRE1α, respectively). Exhibits selectivity for IRE1α in a panel of over 100 other kinases. Harrington et al (2014) Unfolded protein response in cancer: IRE1α inhibition by selective kinase ligands does not impair tumor cell viability. ACS Med.Chem.Lett. 6 68 PMID:25589933 |
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