6-Hydroxy-DL-DOPA 是一种选择性和有效的 RAD52 ssDNA 结合域的变构抑制剂。 6-Hydroxy-DL-DOPA可用于癌症的研究。
| Cas No. | 21373-30-8 |
| 别名 | N,N-二甲基甲酰胺二甲缩醛 |
| Canonical SMILES | OC1=C(O)C=C(O)C(CC(C(O)=O)N)=C1 |
| 分子式 | C9H11NO5 |
| 分子量 | 213.19 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Allosteric inhibitor of RAD52; inhibits RAD52 binding to single strand DNA binding domains (IC50 = 1.1 μM). Selectively inhibits proliferation of BRCA-deficient cancer cells in vitro. Also inhibits APE1. Wilson DM 3rd et al (2010) Small molecule inhibitors of DNA repair nuclease activities of APE1. Cell Mol.Life Sci. 67 3621 PMID:20809131 |Simeonov et al (2009) Identification and characterization of inhibitors of human apurinic/apyrimidinic endonuclease APE1. PLoS One 4 e5740 PMID:19484131 |Chandramouly et al (2015) Small-Molecule Disruption of RAD52 Rings as a Mechanism for Precision Medicine in BRCA-Deficient Cancers. Chem.Biol. 22 1491 PMID:26548611 |
