BS 181 dihydrochloride 是一种比 Seliciclib 有效且选择性的 CDK7 抑制剂 (IC50\u003d21 nM)。 BS-181 还针对 CDK2、CDK5 和 CDK9，IC50 值分别为 880 nM、3000 nM 和 4200 nM（无法阻断 CDK1、4 和 6）。 BS 181 dihydrochloride 抑制一组癌细胞生长 (IC50\u003d11.5 μM-37.3 μM) 并诱导细胞凋亡。 BS 181 dihydrochloride 具有研究癌症治疗的潜力。
| Cas No. | 1883548-83-1 |
| Canonical SMILES | CC(C)C1=C2N=C(NCCCCCCN)C=C(NCC3=CC=CC=C3)N2N=C1.Cl.Cl |
| 分子式 | C22H32N6.2HCl |
| 分子量 | 453.45 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Selective cdk7 inhibitor (IC50 = 21 nM). Displays >40-fold selectivity for cdk7 over others cdks. Promotes cell cycle arrest and apoptosis in a range of cancer cells in vitro and inhibits MCF-7 tumor xenograft growth in mice. Ali et al (2009) The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity. Cancer Res. 69 6208 PMID:19638587 |
