4-oxo-27-TBDMS Withaferin A 是一种 withaferin A 衍生物，对肿瘤细胞具有有效的抗增殖作用。4-oxo-27-TBDMS Withaferin A 可诱导肿瘤细胞凋亡。 4-oxo-27-TBDMS Withaferin A 是一种抗癌剂。
| Cas No. | 1214886-31-3 |
| Canonical SMILES | O=C(C=C1)[C@@]2(C)[C@@]([C@H]3C[C@]4([H])[C@]2([H])CC[C@@]5(C)[C@@]4([H])CC[C@]5([H])[C@H](C)[C@@]6([H])CC(C)=C(CO[Si](C)(C)C(C)(C)C)C(O6)=O)(O3)C1=O |
| 分子式 | C34H50O6Si |
| 分子量 | 582.9 |
| 溶解度 | DMF: 5mg/mL,DMSO: 5mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells. References
1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of withaferin A by incorporating silicon to improve its clinical potential on human ovarian carcinoma cells. J. Med. Chem. 62(9), 4571-4585 (2019). |
