WR99210 是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂，IC50 为 Plasmodium falciparum)。
| Cas No. | 47326-86-3 |
| Canonical SMILES | CC1(N=C(N=C(N1OCCCOC2=C(C=C(C(Cl)=C2)Cl)Cl)N)N)C |
| 分子式 | C14H18Cl3N5O2 |
| 分子量 | 394.68 |
| 溶解度 | DMSO: 5 mg/mL (12.67 mM) |
| 储存条件 | Store at -20°C,unstable in solution, ready to use. |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of Plasmodium falciparum strains[2].
IC50:<0.075 nM (DHFR)[1] [1]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8.
[2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41. |
