| CAS NO: | 1621523-07-6 |
| Cas No. | 1621523-07-6 |
| Canonical SMILES | ClC1=CN=C(NC2=CC(NC(C3=CC=C(NC(CCCN(C)C)=O)C=C3)=O)=CC=C2)N=C1C4=CNC5=CC=CC=C54 |
| 分子式 | C31H30ClN7O2 |
| 分子量 | 568.07 |
| 溶解度 | DMSO: ≥ 100 mg/mL (176.03 mM); Water:< 0.1 mg/mL (insoluble) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | THZ1-R is a non-cysteine reactive analog of THZ1 which displays diminished activity for CDK7 inhibition. THZ1-R binds to CDK7 with a Kd of 142 nM. CDK7|146 nM (IC50) THZ1-R shows lower affinity at CDK7 than THZ1, with IC50 of 146 nM[1]. [1]. Kwiatkowski N, et al. Targeting transcription regulation in cancer with a covalent CDK7 inhibitor. Nature. 2014 Jul 31;511(7511):616-20. |
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