Oroxin B (OB) 是从中草药 Oroxylum indicum (L.) Vent 中分离得到的黄酮类化合物。Oroxin B (OB) 具有明显的抑制作用，通过上调 PTEN、下调 PTEN 诱导肝癌细胞早期凋亡而不是晚期凋亡COX-2、VEGF、PI3K 和 p-AKT.Oroxin B (OB) 在恶性淋巴瘤细胞中选择性诱导肿瘤抑制性 ER 应激。
| Cas No. | 114482-86-9 |
| 别名 | 木蝴蝶苷B |
| 化学名 | 5,6-dihydroxy-2-phenyl-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-((((2R,3R,4S,5S)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-2-yl)oxy)-4H-chromen-4-one |
| Canonical SMILES | OCC1O[C@@H](OC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@H](OC3=CC(OC(C4=CC=CC=C4)=CC5=O)=C5C(O)=C3O)O2)[C@H](O)[C@@H](O)[C@@H]1O |
| 分子式 | C27H30O15 |
| 分子量 | 594.52 |
| 溶解度 | ≥ 59.5mg/mL in DMSO |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Oroxin B (OB) is a flavonoid isolated from traditional Chinese herbal medicine Oroxylum indicum (L.) Vent. Oroxin B (OB) possesses obvious inhibitory effect and induces early apoptosis rather than late apoptosis on liver cancer cells through upregulation of PTEN, down regulation of COX-2, VEGF, PI3K, and p-AKT[1].Oroxin B (OB) selectively induces tumor-suppressive ER stress in malignant lymphoma cells[2]. References:
[1]. Li NN, et al. Evidence for the Involvement of COX-2/VEGF and PTEN/Pl3K/AKT Pathway the Mechanism of Oroxin B Treated Liver Cancer. Pharmacogn Mag. 2018 Apr-Jun;14(54):207-213.
[2]. Yang P, et al. Oroxin B selectively induces tumor-suppressive ER stress and concurrently inhibits tumor-adaptive ER stress in B-lymphoma cells for effective anti-lymphoma therapy. Toxicol Appl Pharmacol. 2015 Oct 15;288(2):269-79. |
