&2#8242;-O-Methylcytidine 是一种 2'-取代的核苷，可作为 HCV 复制的抑制剂。
| Cas No. | 2140-72-9 |
| 别名 | 2'-甲氧基胞苷 |
| Canonical SMILES | [H][C@@]1(N2C(N=C(N)C=C2)=O)O[C@H](CO)[C@H]([C@H]1OC)O |
| 分子式 | C10H15N3O5 |
| 分子量 | 257.2 |
| 溶解度 | DMSO: 0.2 mg/ml,PBS (pH 7.2): 10 mg/ml |
| 储存条件 | 4°C, protect from light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 µM).1It inhibits HCV replication in a replicon assay (IC50= 21.2 µM). 1.Migliaccio, G., Tomassini, J.E., Carroll, S.S., et al.Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitroJ. Bio. Chem.278(49)49164-49170(2003) |
