Dihydrocytochalasin B (H2CB) 是一种细胞分裂抑制剂，会改变细胞的形态，类似于细胞松弛素 B；不抑制葡萄糖转运。二氢细胞松弛素 B (H2CB) 破坏肌动蛋白结构并抑制生长因子刺激 DNA 合成的能力，可逆地阻止 DNA 合成的启动。二氢细胞松弛素 B (H2CB) 抑制主动钙转运并导致黏膜刮屑中的 Ca2+ 增加。
| Cas No. | 39156-67-7 |
| 别名 | 二氢细胞松弛素 B |
| Canonical SMILES | O=C1CC[C@H](O)CCC[C@@H](C)C/C=C/[C@]([C@H](O)C([C@@H](C)[C@@]2([H])[C@H](CC3=CC=CC=C3)NC4=O)=C)([H])[C@@]24O1 |
| 分子式 | C29H39NO5 |
| 分子量 | 481.6 |
| 溶解度 | DMF: 30 mg/mL,DMF:PBS (pH 7.2) (1:20): 0.05 mg/mL,DMSO: 20 mg/mL,Ethanol: 20 mg/mL |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dihydrocytochalasin B (H2CB) is a Cytokinesis inhibitor and changes the morphology of the cells, similar to that of cytochalasin B; does not inhibit glucose transport[1]. Dihydrocytochalasin B (H2CB) disrupts the actin structure and inhibits the ability of growth factors to stimulate DNA synthesis, reversibly blocks initiation of DNA synthesis[2]. Dihydrocytochalasin B (H2CB) inhibits active calcium transport and causes a Ca2+increase in the mucosal scrapings[3]. References:
[1]. Atlas SJ, et al. Dihydrocytochalasin B. Biological effects and binding to 3T3 cells. J Cell Biol. 1978 Feb;76(2):360-70.
[2]. Jande SS, et al. Effects of cytochalasin B and dihydrocytochalasin B on calcium transport by intestinal absorptive cells. Calcif Tissue Int. 1981;33(2):143-51.
[3]. Maness PF, et al. Dihydrocytochalasin B disorganizes actin cytoarchitecture and inhibits initiation of DNA synthesis in 3T3 cells. Cell. 1982 Aug;30(1):253-62. |
