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N-Benzylpalmitamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
N-Benzylpalmitamide图片
CAS NO:74058-71-2
包装与价格:
包装价格(元)
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N-Benzylpalmitamide 是一种从 Lepidium meyenii 中分离出来的 macamide,作为脂肪酸酰胺水解酶 (FAAH) 的抑制剂。
Cas No.74058-71-2
别名N-苄基棕榈酰胺,N-Benzylhexadecanamide
化学名N-(phenylmethyl)-hexadecanamide
Canonical SMILESO=C(CCCCCCCCCCCCCCC)NCC1=CC=CC=C1
分子式C23H39NO
分子量345.6
溶解度≤2mg/ml in organic solvent ethanol
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

N-Benzylpalmitamide is an inhibitor of fatty acid amide hydrolase (FAAH) [1].

The fatty acid amide hydrolase (FAAH) is a mammalian integral membrane enzyme responsible for the hydrolysis of anandamide, an endocannabinoid. The FAAH is involved in degrading the fatty acid amide family of endogenous signaling lipids, including the endogenous cannabinoid anandamide and the sleep-inducing substance oleamide. FAAH belongs to is a member of amidase signature (AS) family. The FAAH integrates into cell membranes and terminates fatty acid amide signaling in vivo [2]. Genetic mutations in FAAH may constitute important risk factors for problem drug use and support a potential link between functional abnormalities in the endogenous cannabinoid system and drug abuse and dependence [3].

N-Benzylpalmitamide was a long-chain fatty acid amide isolated from the maca (L. meyenii) plant and was structurally related to cannabinoids. N-Benzylpalmitamide was a moderate inhibitor of FAAH and inhibited 44% activity of FAAH at 500 μM [1].

References:
[1] Wu H, Kelley C J, Pino-Figueroa A, et al.  Macamides and their synthetic analogs: evaluation of in vitro FAAH inhibition[J]. Bioorganic & medicinal chemistry, 2013, 21(17): 5188-5197.
[2] Deutsch D G, Ueda N, Yamamoto S.  The fatty acid amide hydrolase (FAAH)[J]. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 2002, 66(2): 201-210.
[3] Sipe J C, Chiang K, Gerber A L, et al.  A missense mutation in human fatty acid amide hydrolase associated with problem drug use[J]. Proceedings of the National Academy of Sciences, 2002, 99(12): 8394-8399.

 
 
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