GSK2578215A 是一种有效且高度选择性的 LRRK2 抑制剂，对野生型 LRRK2 和 G2019S 突变体的 IC50 约为 10 nM。
| Cas No. | 1285515-21-0 |
| 别名 | 5-(2-氟-4-吡啶基)-2-(苯基甲氧基)-N-3-吡啶基苯甲酰胺 |
| 化学名 | 2-(benzyloxy)-5-(2-fluoropyridin-4-yl)-N-(pyridin-3-yl)benzamide |
| Canonical SMILES | FC1=NC=CC(C2=CC=C(C(C(NC3=CC=CN=C3)=O)=C2)OCC4=CC=CC=C4)=C1 |
| 分子式 | C24H18FN3O2 |
| 分子量 | 399.42 |
| 溶解度 | ≥ 19.95mg/mL in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | GSK2578215A is a potent and highly selective LRRK2 inhibitor, which exhibits IC50s of around 10 nM against both wild-type LRRK2 and the G2019S mutant. References:
[1]. Reith AD, et al. GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5625-9. |
