PF 750 是一种选择性的共价脂肪酸酰胺水解酶 (FAAH) 抑制剂，在不同的预孵育时间，IC50 为 16.2-595 nM。
| Cas No. | 959151-50-9 |
| 别名 | N-苯基-4-(3-喹啉基甲基)-1-哌啶甲酰胺 |
| 化学名 | N-phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide |
| Canonical SMILES | O=C(NC1=CC=CC=C1)N2CCC(CC3=CC4=CC=CC=C4N=C3)CC2 |
| 分子式 | C22H23N3O |
| 分子量 | 345.44 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.125 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at RT |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PF 750 is a selective and covalent fatty acid amide hydrolase (FAAH) inhibitor, with IC50s varied from 16.2-595 nM in different pre-incubation times. Covalently modifies the enzyme’s active site serine nucleophile[1]. References:
[1]. Ahn K, et al. Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity. Biochemistry. 2007 Nov 13;46(45):13019-30. |
