Ec2la 是一种口服活性大麻素 2 型受体 (CB2Rs) 正变构调节剂。
| Cas No. | 2244579-87-9 |
| Canonical SMILES | CC1=C(C(N(C=C1Br)CC2=CC=C(C=C2)F)=O)NC(C3CCCCCC3)=O |
| 分子式 | C21H24BrFN2O2 |
| 分子量 | 435.33 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | CB2 receptor positive allosteric modulator. Enhances CP 55940 and 2-Arachidonylglycerol -stimulated binding of [35S]GTPγS to CB2 receptors, but has no effect in the absence of agonist. Exhibits antinociceptive effects in an animal model of neuropathic pain. Gado et al (2019) Identification of the first synthetic allosteric modulator of the CB2 receptors and evidence of its efficacy for neuropathic pain relief. J.Med.Chem. 62 276 PMID:29990428 |
