S4 是一种有效的、选择性的碳酸酐酶 IX/XII (CA IX/XII) 抑制剂，其 Ki 值分别为 7 nM 和 2 nM。 S4 还抑制 CA II 和 CA I（Ki 分别为 546 和 5600 nM）。 S4可以抑制原位MDA-MB-231小鼠模型中肺转移的数量，而不影响原发肿瘤的生长。
| Cas No. | 1330061-67-0 |
| Canonical SMILES | NS(OC1=CC=C(NC(NC2=CC(C)=CC(C)=C2)=O)C=C1)(=O)=O |
| 分子式 | C15H17N3O4S |
| 分子量 | 335.38 |
| 溶解度 | DMSO: 30 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | High affinity and selective CA IX and CA XII inhibitor (Ki values are 2, 7, 547 and 5600 nM for CA XII, IX, II and I, respectively). Inhibits migration and proliferation of breast cancer cells in vitro. Inhibits lung metastasis in mice bearing breast tumor xenografts, without affecting primary tumor. Gieling et al (2012) Antimetastatic effect of sulfamate carbonic anhydrase IX inhibitors in breast carcinoma xenografts. J.Med.Chem. 55 5591 PMID:22621623 |
