ABP 688 是一种高亲和力人 mGluR5 拮抗剂，anKi 为 1.7 nM。
| Cas No. | 924298-51-1 |
| Canonical SMILES | CC1=CC=CC(C#CC(CCC2)=C/C2=N/OC)=N1 |
| 分子式 | C15H16N2O |
| 分子量 | 240.3 |
| 溶解度 | DMSO: 100 mM |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | High affinity human mGlu5 receptor antagonist (Ki = 1.7 nM). Inhibits glutamate-induced calcium release from L(tk-) cells expressing human mGlu5 receptors (IC50 = 2.3 nM). Hintermann et al (2007) ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. Bioorg.Med.Chem. 15 903 PMID:17110115 |
