3,5-二碘甲状腺丙酸是一种甲状腺激素类似物，可诱导 α-肌球蛋白重链 mRNA 表达，与甲状腺激素受体 (TR) 结合，TRα1 和 TRβ1 的 Ka 分别为 2.40 和 4.06 M-1 。
| Cas No. | 1158-10-7 |
| 别名 | 3,5-二碘甲腺丙酸 |
| 化学名 | 4-(4-hydroxyphenoxy)-3,5-diiodo-benzenepropanoic acid |
| Canonical SMILES | IC1=CC(CCC(O)=O)=CC(I)=C1OC2=CC=C(O)C=C2 |
| 分子式 | C15H12I2O4 |
| 分子量 | 510.1 |
| 溶解度 | DMSO: Slightly Soluble,Methanol: Slightly Soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 3,5-Diiodothyropropionic acid (DITPA) is an inotropic thyroid hormone analogue of L-thyroxine that binds to the thyroid hormone receptors TRα and TRβ (Kas = 2.4 and 4.06 x 107 M-1, respectively, for human recombinant receptors).1 DITPA increases mRNA expression of α-myosin heavy chain (α-MHC) in primary rat cardiomyocytes (EC50 = ~0.5 μM). Ex vivo, DITPA prevents myocardial infarction-induced loss of contractility in rabbit cardiomyocytes when administered at a dose of 3.75 mg/kg per day.2 DITPA (3.75 mg/kg per day) increases expression of VEGF, basic fibroblast growth factor (bFGF), angiopoietin-1, and angiopoietin-1 receptor (Tie-2) as well as angiogenesis in non-infarcted cardiac tissue in rats.3 It also decreases infarct size expansion, stimulates arteriolar growth, and inhibits ventricular remodeling post-myocardial infarction in rats when administered at a dose of 3.5 mg/kg per day.4 |
