首页 蛋白库 基因库 产品 会员服务
位置：首页 > 产品库 > CD 2314
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
CD 2314
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
CD 2314图片
CAS NO:170355-37-0
包装与价格：
包装价格(元)
10mg询价
50mg询价

CD 2314 是一种有效的选择性 RARβ 受体激动剂，在 S91 黑色素瘤细胞中的 Kd 为 195 nM。
Cas No.170355-37-0
化学名5-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydroanthracen-2-yl)thiophene-3-carboxylic acid
Canonical SMILESCC(CCC1(C)C)(C2=C1C=C3C=C(C4=CC(C(O)=O)=CS4)C=CC3=C2)C
分子式C23H24O2S
分子量364.5
溶解度<36.45mg/ml in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

CD 2314 is a potent and selective agonist of RARβ with Kd value of 145 and >3760 nM for RARβ and RARα receptors, respectively [1].

Retinoic acid receptor β (RARβ) is a nuclear receptor for retinoic acid and localizes to the cytoplasm and subnuclear compartments. RARβ mediates cellular signalling in cell growth, differentiation and embryonic morphogenesis.

CD 2314 is a potent and selective RARβ agonist. CD 2314 didn’t inhibit the activation-induced apoptosis of thymocytes because of the absent of RARβ in the thymus [1]. CD 2314 inhibited cells growth with IC50 values of 8.0, 3.0, 5.7 and >10 μM for human head and neck squamous cell carcinoma (HNSCC) 22A, 22B, 183A and 886 cell lines, respectively. In UMSCC22B cells, the combination of CD2314 with RXR-selective retinoids, such as SR11234, SR11203, SR11246 and SR11236 inhibited cells growth [2]. In KG-1 cells, CD 2314 didn’t induce folate receptor β (FR-β) expression, indicating that the induction of FR-β was not mediated by RARβ [3].

References:
[1].  Szondy Z, Reichert U, Bernardon JM, et al. Inhibition of activation-induced apoptosis of thymocytes by all-trans- and 9-cis-retinoic acid is mediated via retinoic acid receptor alpha. Biochem J, 1998, 331 ( Pt 3): 767-774.
[2].  Sun SY, Yue P, Mao L, et al. Identification of receptor-selective retinoids that are potent inhibitors of the growth of human head and neck squamous cell carcinoma cells. Clin Cancer Res, 2000, 6(4): 1563-1573.
[3].  Xu Y, Wang T, Tang R, et al. All-trans retinoic acid is capable of inducing folate receptor β expression in KG-1 cells. Tumour Biol, 2010, 31(6): 589-595.

 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024