| 包装 | 价格(元) |
| 1mg | 询价 |
| 5mg | 询价 |
| Canonical SMILES | ClC(C=C1)=CC=C1C(OCCN(C([2H])([2H])[2H])C([2H])([2H])[2H])C2=CC=CC=N2.OC(/C=C\C(O)=O)=O |
| 分子式 | C16H13ClD6N2O·C4H4O4 |
| 分子量 | 412.9 |
| 溶解度 | Acetonitrile: soluble,DMSO: soluble |
| 储存条件 | -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Carbinoxamine-d6is intended for use as an internal standard for the quantification of carbinoxamine by GC- or LC-MS. Carbinoxamine is a competitive histamine H1receptor antagonist (Ki= 2.3 nM) and first generation antihistamine.1It is also an L-type calcium channel inhibitor (Ki= 1.08 nM).2Carbinoxamine decreases negative inotropic activity in isolated guinea pig left atria and negative chronotropic activity in guinea pig spontaneously beating isolated right atria (EC50s = 250 and 480 nM, respectively). Formulations containing carbinoxamine have been used in the treatment of allergic rhinitis. 1.Tran, V.T., Chang, R.S.L., and Snyder, S.H.Histamine H1 receptors identified in mammalian brain membranes with [3H]mepyramineProc. Natl. Acad. Sci. U.S.A.75(12)6290-6294(1978) 2.Carosati, E., Budriesi, R., Ioan, P., et al.Discovery of novel and cardioselective diltiazem-like calcium channel blockers via virtual screeningJ. Med. Chem.51(18)5552-5565(2008) |
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