Tryptamine-d₄is intended for use as an internal standard for the quantification of tryptamine by GC- or LC-MS. Tryptamine is an indole alkaloid and intermediate in the biosynthesis of serotonin and the phytohormone melatonin in plants.^1,2It increases levels of the terpenoid indole alkaloids ajmalicine , strictosidine, and catharanthine in cultures ofC. roseus.³Tryptamine is also a product of tryptophan metabolism in mammals.⁴Tryptamine derivatives have been synthetically produced as hallucinogenic drugs of abuse that act on the serotonergic system.⁵

1.Arnao, M.B.Phytomelatonin: Discovery, content, and role in plantsAdv. Bot.2014:815769(2014) 2.Fan, J., Xie, Y., Zhang, Z., et al.Melatonin: A multifunctional factor in plantsInt. J. Mol. Sci.19(5)E1528(2018) 3.Almagro, L., FernÁndez-PÉrez, F., and PedreÑo, M.A.Indole alkaloids from Catharanthus roseus: Bioproduction and their effect on human healthMolecules20(2)2973-3000(2015) 4.Berumen, L.C., RodrÍguez, A., Miledi, R., et al.Serotonin receptors in hippocampusSci. World J.2012:823493(2012) 5.Araujo, A.M., Carvalho, F., Bastos, M.L., et al.The hallucinogenic world of tryptamines: An updated reviewArch. Toxicol.89(8)1151-1173(2015)