Dihydroberberine 可抑制人类以太相关基因 (hERG) 通道，显着降低热休克蛋白 90 (Hsp90) 的表达及其与 hERG 的相互作用。Dihydroberberine 具有抗炎，抗动脉粥样硬化，降血脂和抗肿瘤活性。
| Cas No. | 483-15-8 |
| 别名 | 二氢小檗碱 |
| Canonical SMILES | COC1=CC=C(C=C23)C(CN2CCC(C3=C4)=CC5=C4OCO5)=C1OC |
| 分子式 | C20H19NO4 |
| 分子量 | 337.37 |
| 溶解度 | Soluble in DMSO |
| 储存条件 | Store at -20°C,sealed storage, away from moisture and light |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1]. [1]. Yu D, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017 Aug 1;12(8):e0181823. |
