KRM-III 是一种有效的具有口服活性的 T 细胞抗原受体 (TCR) 抑制剂。KRM-III 抑制 TCR 和肉豆蔻酸乙酸酯/佛波霉素/离子霉素诱导的 NFAT 核因子活化和 T 细胞增殖，IC50 约为 5 μM。抗炎活性。
| Cas No. | 79220-94-3 |
| 分子式 | C15H12N2S |
| 分子量 | 252.33 |
| 溶解度 | DMSO : 100 mg/mL (396.31 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | KRM-III is a potent and orally active T-cell antigen receptor (TCR) inhibitor. KRM-III inhibits TCR- and phorbol myristate acetate/ionomycin-induced activation of nuclear factor of activated T cells (NFAT) and T-cell proliferation with an IC50 of ~5 μM. Anti-inflammatory activity[1]. [1]. Eun Joo Jung, et al. Oral administration of 1,4-aryl-2-mercaptoimidazole inhibits T-cell proliferation and reduces clinical severity in the murine experimental autoimmune encephalomyelitis model. J Pharmacol Exp Ther. 2009 Dec;331(3):1005-13. |
