LTβR-IN-1 是一种有效的，选择性淋巴毒素β受体 (LTβR) 抑制剂，IC50 为 10 μM。LTβR-IN-1 对 TWEAK 刺激的 p52 易位测定中的 IC50 为 10 μM，LTβR-IN-1 不改变 TNF-α 诱导的 p65 核转位。
| Cas No. | 2189366-77-4 |
| 分子式 | C18H16N4O2 |
| 分子量 | 320.35 |
| 溶解度 | DMSO : 125 mg/mL (390.20 mM; Need ultrasonic) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α-induced p65 nuclear translocation[1]. [1]. Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541). |
