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MASM7
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
MASM7图片
CAS NO:920868-45-7
包装:10mg
市场价:3240元

MASM7 是一种 mitofusin 激活剂，可通过 mitfusins 实现线粒体融合。MASM7 可浓度响应性增加 Mito AR，在MEFs 细胞中 EC50 值为 75 nM，并可通过直接激活 MFN2 或 MFN 促进线粒体融合。MASM7 还可与 MFN2 的 HR2 结构域直接结合，其 Kd 值为 1.1 μM。
Cas No.920868-45-7
分子式C22H23N5O2S2
分子量453.58
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MASM7 is a mitofusin activator, and can achieve mitochondrial fusion via mitofusins. MASM7 can increase Mito AR with anEC50value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN. MASM7 also demonstrates direct binding to the HR2 domain of MFN2 withKdvalue of 1.1 μM[1].

MASM7 (1-10 μM, 2 h) increases Mito AR with an EC50value of 75 nM in MEFs in concentration-responsively, and can promote mitochondrial fusion by directly activating MFN2 or MFN[1].
MASM7 (1-1000 μM, 5 min) demonstrates direct binding to the HR2 domain of MFN2 with Kdvalue of 1.1 μM[1].
MASM7 (1 μM, 6 h) does not induce DNA damage in any of the cell lines[1].
MASM7 (0-1.5 μM, 72 h) does not decrease cellular viability over the course of 72 h[1].
MASM7 (1 μμ, 6 h) does not induce caspase-3/7 activation in U2OS cells[1].
MASM7 (0-1 μM, 6 h) increases mitochondrial membrane potential in WT MEFs[1].

 
 
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