| CAS NO: | 212779-48-1 |
| Cas No. | 212779-48-1 |
| 别名 | 2-[[6-[(3-氯苯基)氨基]-9-异丙基-9H-嘌呤-2-基]氨基]乙醇,Compound 52 |
| Canonical SMILES | ClC1=CC(NC2=NC(NCCO)=NC3=C2N=CN3C(C)C)=CC=C1 |
| 分子式 | C16H19ClN6O |
| 分子量 | 346.81 |
| 溶解度 | DMSO: 100 mg/mL (288.34 mM) |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM). cdc2-cyclin B|0.34 μM (IC50)|Pho85p|2 nM (IC50) [1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. |
| 维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024 |