| CAS NO: | 2070009-25-3 |
| 包装: | 1mg |
| 市场价: | 5670元 |
| Cas No. | 2070009-25-3 |
| 别名 | 索菲布韦杂质 |
| Canonical SMILES | O=C(NC(C=C1)=O)N1[C@H]2[C@@](F)([13C]([2H])([2H])[2H])[C@H](O)[C@@H](CO[P@@](N[C@@H](C)C(OC(C)C)=O)(OC3=CC=CC=C3)=O)O2 |
| 分子式 | C21[13C]H26D3FN3O9P |
| 分子量 | 533.5 |
| 溶解度 | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml,PBS (pH 7.2): 0.2 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | PSI-7977-13C-d3is intended for use as an internal standard for the quantification of PSI-7977 by GC- or LC-MS. PSI-7977 is a phosphoramidate prodrug of PSI-7851, a nucleoside analog that, when phosphorylated, inhibits the RNA-dependent RNA polymerase of hepatitis C virus (EC50= 92 nM).1,2,3PSI-7977 is effectivein vitroandin vivo.2,4,5 1.Murakami, E., Tolstykh, T., Bao, H., et al.Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977J. Biol. Chem.285(45)34337-34347(2010) 2.Sofia, M.J., Bao, D., Chang, W., et al.Discovery of a β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virusJ. Med. Chem.53(19)7202-7218(2010) 3.Lam, A.M., Espiritu, C., Bansal, S., et al.Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virusAntimicrob. Agents Chemother.56(6)3359-3368(2012) 4.Gane, E.J., Stedman, C.A., Hyland, R.H., et al.Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis CN. Engl. J. Med.368(1)34-44(2013) 5.Lawitz, E., Mangia, A., Wyles, D., et al.Sofosbuvir for previously untreated chronic hepatitis C infectionN. Engl. J. Med.368(20)1878-1887(2013) |
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