Propiconazole is a broad-spectrum triazole fungicide that inhibits the conversion of lanosterol to ergosterol, leading to fungal cell membrane disruption.¹It inhibitsS. cerevisiae, but not rat liver, microsomal cytochrome P450 (IC₅₀s = 0.04 and >200 µM, respectively).²Propiconazole inhibits the growth ofT. deformansandR. stolonifer(EC₅₀s = 0.073 and 4.6 µg/ml, respectively), as well asA. niger,M. fructigena,S. nodorum,T. harzanium,R. solani, andS. rolfsiiat concentrations ranging from 0.1 to 5 ppm.³It increases the weight of seminal vesicles and vas deferens, as well as the percentage of sperm with abnormal tail morphology, and decreases the plasma concentration of estradiol in male rats when administered at a dose of 4 mg/kg.⁴Propiconazole increases production of reactive oxygen species (ROS), the number of DNA mutations, and the incidence of tumor formation in mouse liver.⁵Formulations containing propiconazole have been used in the control of fungi in agriculture.

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