| CAS NO: | 145603-76-5 |
| 包装: | 1mg |
| 市场价: | 3402元 |
| Cas No. | 145603-76-5 |
| Canonical SMILES | C=C1CC[C@]([C@@](CC/C=C(C)/C)(C)[C@@H](OC(C)=O)CC2)([H])[C@@]2(C)[C@@H]1CC3=C(OC)OC(C)=C(C)C3=O |
| 分子式 | C30H44O5 |
| 分子量 | 484.7 |
| 溶解度 | Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Nalanthalide is a diterpenoid pyrone fungal metabolite that has been found inNalanthamalaand has potassium channel inhibitory and antiviral activities.1It inhibits binding of the potassium channel inhibitor charybdotoxin to Jurkat cell membranes (IC50= 3 µM) and inhibits rubidium efflux from CHO cells expressing the voltage-gated potassium (Kv) channel Kv1.3 (IC50= 3.9 µM). Nalanthalide depolarizes T cellsin vitrowith an EC50value of 500 nM. It also inhibits HIV-1 integrase activity with IC50values of 10 and 25 µM in coupled and strand transfer assays, respectively.2 1.Goetz, M.A., Zink, D.L., Dezeny, G., et al.Diterpenoid pyrones, novel blockers of the voltage-gated potassium channel Kv1.3 from fungal fermentationsTetrahedron Lett.42(7)1255-1257(2001) 2.Singh, S.B., Jayasuriya, H., Dewey, R., et al.Isolation, structure, and HIV-1-integrase inhibitory activity of structurally diverse fungal metabolitesJ. Ind. Microbiol. Biotechnol.30(12)721-731(2003) |
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